Structural features and development of an assay platform of the parasite target deoxyhypusine synthase of Brugia malayi and Leishmania major.

• 主要な著者: Suélen Fernandes Silva (著者), Angélica Hollunder Klippel (著者), Priscila Zonzini Ramos (著者), André da Silva Santiago (著者), Sandro Roberto Valentini (著者), Mario Henrique Bengtson (著者), Katlin Brauer Massirer (著者), Elizabeth Bilsland (著者), Rafael Miguez Couñago (著者), Cleslei Fernando Zanelli (著者)
• フォーマット: 図書
• 出版事項: Public Library of Science (PLoS), 2020-10-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Deoxyhypusine synthase (DHS) catalyzes the first step of the post-translational modification of eukaryotic translation factor 5A (eIF5A), which is the only known protein containing the amino acid hypusine. Both proteins are essential for eukaryotic cell viability, and DHS has been suggested as a goo...