Structural features and development of an assay platform of the parasite target deoxyhypusine synthase of Brugia malayi and Leishmania major.

• Главные авторы: Suélen Fernandes Silva (Автор), Angélica Hollunder Klippel (Автор), Priscila Zonzini Ramos (Автор), André da Silva Santiago (Автор), Sandro Roberto Valentini (Автор), Mario Henrique Bengtson (Автор), Katlin Brauer Massirer (Автор), Elizabeth Bilsland (Автор), Rafael Miguez Couñago (Автор), Cleslei Fernando Zanelli (Автор)
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• Опубликовано: Public Library of Science (PLoS), 2020-10-01T00:00:00Z.
• Предметы: article
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Deoxyhypusine synthase (DHS) catalyzes the first step of the post-translational modification of eukaryotic translation factor 5A (eIF5A), which is the only known protein containing the amino acid hypusine. Both proteins are essential for eukaryotic cell viability, and DHS has been suggested as a goo...