Neuropsychotoxicity of Abused Drugs: Effects of Serotonin Receptor Ligands on Methamphetamine- and Cocaine-Induced Behavioral Sensitization in Mice
Repeated administration of psychostimulants elicits a progressive enhancement of locomotor activity known as behavioral sensitization. Central dopamine (DA) neurons play key roles as the neural substrates mediating behavioral sensitization, but the role of the serotonin (5-HT) system in the sensitiz...
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| Format: | Book |
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Elsevier,
2008-01-01T00:00:00Z.
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| LEADER | 00000 am a22000003u 4500 | ||
|---|---|---|---|
| 001 | doaj_d57e9f7a35f748f5aa6a93583d0c8ee6 | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Yukio Ago |e author |
| 700 | 1 | 0 | |a Shigeo Nakamura |e author |
| 700 | 1 | 0 | |a Akemichi Baba |e author |
| 700 | 1 | 0 | |a Toshio Matsuda |e author |
| 245 | 0 | 0 | |a Neuropsychotoxicity of Abused Drugs: Effects of Serotonin Receptor Ligands on Methamphetamine- and Cocaine-Induced Behavioral Sensitization in Mice |
| 260 | |b Elsevier, |c 2008-01-01T00:00:00Z. | ||
| 500 | |a 1347-8613 | ||
| 500 | |a 10.1254/jphs.FM0070121 | ||
| 520 | |a Repeated administration of psychostimulants elicits a progressive enhancement of locomotor activity known as behavioral sensitization. Central dopamine (DA) neurons play key roles as the neural substrates mediating behavioral sensitization, but the role of the serotonin (5-HT) system in the sensitization is not fully elucidated. We have recently demonstrated that osemozotan, a specific 5-HT1A-receptor agonist, and ritanserin, a 5-HT2-receptor antagonist, inhibited the expression and development of both methamphetamine- and cocaine-induced behavioral sensitization in mice and that these drugs attenuated the maintenance of behavioral sensitization of methamphetamine, but not that of cocaine. We also found that azasetron, a 5-HT3-receptor antagonist, inhibited the expression and development of the sensitization induced by methamphetamine and cocaine, respectively. Neurochemical studies using a microdialysis technique showed that repeated methamphetamine enhanced the methamphetamine-induced increase in 5-HT release in the prefrontal cortex. The sensitization of 5-HT release in methamphetamine-treated mice was attenuated by osemozotan and ritanserin. These findings suggest that the 5-HT system plays an important role in methamphetamine- and cocaine-induced behavioral sensitization in mice and imply that 5-HT1A-receptor agonists and 5-HT2-receptor antagonists may have a potential therapeutic value for the treatment of methamphetamine abuse or psychosis. Keywords:: drugs of abuse, behavioral sensitization, methamphetamine, cocaine, serotonin (5-HT)-receptor ligand | ||
| 546 | |a EN | ||
| 690 | |a Therapeutics. Pharmacology | ||
| 690 | |a RM1-950 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Journal of Pharmacological Sciences, Vol 106, Iss 1, Pp 15-21 (2008) | |
| 787 | 0 | |n http://www.sciencedirect.com/science/article/pii/S1347861319315312 | |
| 787 | 0 | |n https://doaj.org/toc/1347-8613 | |
| 856 | 4 | 1 | |u https://doaj.org/article/d57e9f7a35f748f5aa6a93583d0c8ee6 |z Connect to this object online. |