N-Substituted Pyrido-1,4-Oxazin-3-Ones Induce Apoptosis of Hepatocellular Carcinoma Cells by Targeting NF-κB Signaling Pathway

• Main Authors: Chakrabhavi Dhananjaya Mohan (Author), Hanumantharayappa Bharathkumar (Author), Dukanya (Author), Shobith Rangappa (Author), Muthu K. Shanmugam (Author), Arunachalam Chinnathambi (Author), Sulaiman Ali Alharbi (Author), Tahani Awad Alahmadi (Author), Atanu Bhattacharjee (Author), Peter E. Lobie (Author), Amudha Deivasigamani (Author), Kam Man Hui (Author), Gautam Sethi (Author), Basappa (Author), Kanchugarakoppal S. Rangappa (Author), Alan Prem Kumar (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Hepatocellular carcinoma (HCC) is a fatal disease and ranked fifth in cancer related mortality. Persistent activation of NF-κB is responsible for the oncogenesis, metastasis, tumor evasion, anti-apoptosis, angiogenesis and proliferation in HCC. Therefore, designing of chemically novel, biologically...