Gallic Acid-Dextran Conjugate: Green Synthesis of a Novel Antioxidant Molecule
A novel derivative of dextran, dextran−gallic acid (Dex−Gal), obtained from simple conjugation with gallic acid, was synthesized by an efficient free radical-mediated method. To verify the synthesis of Dex−Gal, 1H-nuclear magnetic resonance (1H-NMR), Fourier transform i...
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| Format: | Book |
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MDPI AG,
2019-10-01T00:00:00Z.
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| LEADER | 00000 am a22000003u 4500 | ||
|---|---|---|---|
| 001 | doaj_d5afcf3f93f14d4fbc47c4a2a3b1bf9d | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Moacir Fernandes Queiroz |e author |
| 700 | 1 | 0 | |a Diego Araujo Sabry |e author |
| 700 | 1 | 0 | |a Guilherme Lanzi Sassaki |e author |
| 700 | 1 | 0 | |a Hugo Alexandre Oliveira Rocha |e author |
| 700 | 1 | 0 | |a Leandro Silva Costa |e author |
| 245 | 0 | 0 | |a Gallic Acid-Dextran Conjugate: Green Synthesis of a Novel Antioxidant Molecule |
| 260 | |b MDPI AG, |c 2019-10-01T00:00:00Z. | ||
| 500 | |a 2076-3921 | ||
| 500 | |a 10.3390/antiox8100478 | ||
| 520 | |a A novel derivative of dextran, dextran−gallic acid (Dex−Gal), obtained from simple conjugation with gallic acid, was synthesized by an efficient free radical-mediated method. To verify the synthesis of Dex−Gal, 1H-nuclear magnetic resonance (1H-NMR), Fourier transform infrared (FTIR) spectrometry, and high-performance size-exclusion chromatography (HPSEC) were employed. The results revealed the conjugation of gallic acid with the 15.5 kDa dextran from <i>Leuconostoc mesenteroides</i>. Dex−Gal had a molecular weight of 11.2 kDa, indicating that the conjugation reaction was accompanied by a minor degradation of Dex−Gal. In addition, Dex−Gal contained 36.8 ± 1.4 mg gallic acid per gram dextran. These molecules were also evaluated as antioxidants using total antioxidant capacity (TAC), reducing power, ferric chelation, and superoxide radical-scavenging assays. Both polysaccharides had no ferric chelation activity. In addition, Dex−Gal was more efficient as an antioxidant agent in TAC (13 times) and was more efficient than dextran in superoxide radical-scavenging (60 times) and reducing power (90 times) assays. These data demonstrate that Dex−Gal is a natural-compound-based antioxidant with potential applications in the pharmaceutical, cosmetic, and food industries. | ||
| 546 | |a EN | ||
| 690 | |a gallic acid-grafted dextran | ||
| 690 | |a <i>leuconostoc</i> dextran | ||
| 690 | |a antioxidant polysaccharide | ||
| 690 | |a Therapeutics. Pharmacology | ||
| 690 | |a RM1-950 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Antioxidants, Vol 8, Iss 10, p 478 (2019) | |
| 787 | 0 | |n https://www.mdpi.com/2076-3921/8/10/478 | |
| 787 | 0 | |n https://doaj.org/toc/2076-3921 | |
| 856 | 4 | 1 | |u https://doaj.org/article/d5afcf3f93f14d4fbc47c4a2a3b1bf9d |z Connect to this object online. |