Effect of blastocyst morphology on the incidence of monozygotic twinning pregnancy after single blastocyst transfer
Aims: To explore whether blastocyst morphology [blastocyst stage, inner cell mass (ICM), and trophectoderm (TE) grading] impacts the occurrence of monozygotic twinning (MZT) after single blastocyst transfer (SBT).Materials and methods: A single-center retrospective cohort study was conducted includi...
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Taylor & Francis Group,
2023-12-01T00:00:00Z.
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| LEADER | 00000 am a22000003u 4500 | ||
|---|---|---|---|
| 001 | doaj_d5be0aaa40834e98b19a37c62a8ed5d1 | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Xiaofei Ge |e author |
| 700 | 1 | 0 | |a Jiaxin Zhang |e author |
| 700 | 1 | 0 | |a Hao Shi |e author |
| 700 | 1 | 0 | |a Zhiqin Bu |e author |
| 245 | 0 | 0 | |a Effect of blastocyst morphology on the incidence of monozygotic twinning pregnancy after single blastocyst transfer |
| 260 | |b Taylor & Francis Group, |c 2023-12-01T00:00:00Z. | ||
| 500 | |a 10.1080/09513590.2023.2228434 | ||
| 500 | |a 1473-0766 | ||
| 500 | |a 0951-3590 | ||
| 520 | |a Aims: To explore whether blastocyst morphology [blastocyst stage, inner cell mass (ICM), and trophectoderm (TE) grading] impacts the occurrence of monozygotic twinning (MZT) after single blastocyst transfer (SBT).Materials and methods: A single-center retrospective cohort study was conducted including all clinical pregnancies after single blastocyst transfer between January 2015 and September 2021 (n = 9229). Blastocyst morphology was assessed using Gardner grading system. MZT was defined as more than one gestational sac (GS), or two or more fetal heartbeats in a single GS via ultrasound at 5-6 gestational weeks.Results: The overall MZT rate was 2.46% (227 of 9229 cases), of which was the highest in blastocysts of grade A TE and lowest in those with grade C TE (grade A: B:C = 3.40%:2.67%:1.58%, p = .002). Higher risk of MZT pregnancy was associated with higher trophectoderm grading [A vs. C: aOR, 1.883, 95% CI 1.069-3.315, p = .028; B vs C: aOR, 1.559, 95% CI 1.066-2.279, p = .022], but not extended culture in vitro (day 5 vs. day 6), vitrification (fresh vs. frozen-thawed ET), assisted hatching (AH), blastocyst stage (stage 1-6) or ICM grading (A vs. B).Conclusions: We conclude that TE grade is an independent risk factor of MZT after single blastocyst transfer. Blastocysts with high-grade trophectoderm are more liable to obtain monozygotic multiple gestation. | ||
| 546 | |a EN | ||
| 690 | |a Monozygotic twinning | ||
| 690 | |a blastocyst morphology | ||
| 690 | |a trophectoderm | ||
| 690 | |a single blastocyst transfer | ||
| 690 | |a Gynecology and obstetrics | ||
| 690 | |a RG1-991 | ||
| 690 | |a Diseases of the endocrine glands. Clinical endocrinology | ||
| 690 | |a RC648-665 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Gynecological Endocrinology, Vol 39, Iss 1 (2023) | |
| 787 | 0 | |n https://www.tandfonline.com/doi/10.1080/09513590.2023.2228434 | |
| 787 | 0 | |n https://doaj.org/toc/0951-3590 | |
| 787 | 0 | |n https://doaj.org/toc/1473-0766 | |
| 856 | 4 | 1 | |u https://doaj.org/article/d5be0aaa40834e98b19a37c62a8ed5d1 |z Connect to this object online. |