Endothelial biomarkers in critically-ill COVID-19 patients: potential predictors of the need for dialysis

• Main Authors: Marza de Sousa Zaranza (Author), Gdayllon Cavalcante Meneses (Author), Reinaldo Barreto Oriá (Author), Alice Maria Costa Martins (Author), Natalia Linhares Ponte Aragão (Author), Nilcyeli Linhares Aragão (Author), Saskya Roberta Rodrigues de Andrade (Author), Nicole Coelho Lopes (Author), Letícia Machado de Araújo (Author), Ranieri Sales de Souza Santos (Author), Álvaro Rolim Guimarães (Author), Ana Paula Pires Lázaro (Author), Andrea Mazza Beliero (Author), Márcia Maria Pinheiro Dantas (Author), Sandra Mara Brasileiro Mota (Author), Geraldo Bezerra da Silva Júnior (Author), Polianna Lemos Moura Moreira Albuquerque (Author), Elizabeth De Francesco Daher (Author)
• Format: Book
• Published: Karger Publishers, 2023-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

Introduction: To evaluate the function of vascular biomarkers to predict need for hemodialysis in critically-ill patients with COVID-19. Methods: This is a prospective study with 58 critically-ill patients due to COVID-19 infection. Laboratory tests in general and vascular biomarkers, such as VCAM-1, Syndecan-1, Angiopoietin-1 and Angiopoeitin-2 were quantified on intensive care unit (ICU) admission. Results: There was a 40% death rate. VCAM and Ang-2/Ang-1 ratio on ICU admission were associated with need for hemodialysis. Vascular biomarkers (VCAM-1, Syndecan-1, angiopoetin-2/ anogiopoetin-1 ratio) were predictors of death and their cut-off values were useful to stratify patients with a worse prognosis. In the multivariate cox regression analysis with adjusted models, VCAM-1 [O.R. 1.13 (C.I. 95%: 1.01 - 1.27); p= 0.034] and Ang-2/Ang-1 ratio [O.R. 4.87 (C.I.95%: 1.732 - 13.719); p= 0.003] were associated with need for dialysis. Conclusion: Vascular biomarkers, mostly VCAM-1 and Ang-2/Ang-1 ratio, showed better efficiency to predict need for hemodialysis in critically-ill COVID-19 patients.

Item Description

1423-0143
10.1159/000535035