Identification of Compounds With Glucocorticoid Sparing Effects on Suppression of Chemokine and Cytokine Production by Rheumatoid Arthritis Fibroblast-Like Synoviocytes

• Main Authors: Tadashi Hosoya (Author), Nikunj M. Shukla (Author), Yuya Fujita (Author), Shiyin Yao (Author), Fitzgerald S. Lao (Author), Hiroyuki Baba (Author), Shinsuke Yasuda (Author), Howard B. Cottam (Author), Dennis A. Carson (Author), Tomoko Hayashi (Author), Maripat Corr (Author)
• Format: Book
• Published: Frontiers Media S.A., 2020-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In recent years target based drug discovery has expanded our therapeutic armamentarium in the treatment of inflammatory and autoimmune diseases. Despite these advances and adverse effects, glucocorticoids remain reliable agents that are used in many of these diseases. The anti-inflammatory mechanism...