Anti-parasitic Activity of Some Medicinal Plants Essential Oils on Giardia lamblia and Entamoeba histolytica, In Vitro

• Main Authors: Mohammad Azadbakht (Author), Aroona Chabra* (Author), Ali Saeedi Akbarabadi (Author), Mohammad Hossein Motazedian (Author), Taha Monadi (Author), Fatemeh Akbari (Author)
• Format: Book
• Published: Iranian Society of Pharmacognosy, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

<strong>Background and objectives:</strong> Giardiasis and amoebiasis are two common diseases in human societies which make increasing problems for the health managing systems. In the present study, the antiparasitic activity of <em>Allium sativum</em>, <em>Artemisia sieberi</em>, <em>Zatraria multiflora</em>, <em>Chenopodium botrys</em> and <em>Eucalyptus globulus</em> essential oils on <em>Giardia lamblia</em> cysts and <em>Entamoeba histolytica</em> trophozoites were investigated in vitro. <strong>Methods: </strong><em>Giardia lamblia</em> cysts and <em>E. histolytica</em> trophozoites were isolated from infected sample stools. The parasites were treated by four concentrations (0.2, 0.1, 0.01 and 0.001 µg/mL) of essential oils, separately for 30 min at 37 °C.<strong> Results: </strong>Theessential oils at the concentration of 0.1 and 0.2 µg/mL indicated appreciate parasiticidal effect (p<0.05).  <em>Eucalyptus globulus</em> had maximum efficacy on both <em>G. lamblia</em> and <em>E. histolytica</em> with mortality rates of 79.7% and 87.6% within 30 min. <strong>Conclusion:</strong> All essential oils showed potent anti-giardiasis and anti-amoebiasis activity. Also, <em>E. globulus</em> with the highest efficiency could be considered as anti-protozoa medication to use an adjunct or primary therapy.

Item Description

2345-4458
2345-5977
10.22127/rjp.2019.168142.1462