Comparative study of the neuroprotective activity of lithium compounds and their effect on the course of experimental alloxan diabetes mellitus in rats
A comparative study of the effects of an inorganic lithium salt (lithium carbonate) and an organic lithium salt (lithium ascorbate) on a model of alloxan diabetes mellitus was conducted. The use of lithium ascorbate for a month in experimental alloxan diabetes mellitus facilitates its course - the s...
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| Main Authors: | , , , , |
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| Format: | Book |
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LLC "Publisher OKI",
2021-06-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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| Summary: | A comparative study of the effects of an inorganic lithium salt (lithium carbonate) and an organic lithium salt (lithium ascorbate) on a model of alloxan diabetes mellitus was conducted. The use of lithium ascorbate for a month in experimental alloxan diabetes mellitus facilitates its course - the survival rate of animals increases, the level of glycemia decreases (especially when administered at a dose of 10 mg/kg). Morphometric analysis showed that lithium ascorbate in alloxan diabetes has a neuroprotective effect, which is manifested in a decrease in toxic damage to neurocytes with an increase in the number of cells with reversible changes and intact neurons. Lithium carbonate at doses of 5 and 10 mg / kg was not effective. |
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| Item Description: | 2587-7836 2686-8830 10.37489/2587-7836-2020-3-40-47 |