Cover Image

Monoclonal antibody targeting mu-opioid receptor attenuates morphine tolerance via enhancing morphine-induced receptor endocytosis

Morphine is a frequently used analgesic that activates the mu-opioid receptor (MOR), which has prominent side effects of tolerance. Although the inefficiency of morphine in inducing the endocytosis of MOR underlies the development of morphine tolerance, currently, there is no effective therapy to tr...

Full description

Saved in:

Bibliographic Details
Main Authors:	Jia-Jia Zhang (Author), Chang-Geng Song (Author), Miao Wang (Author), Gai-Qin Zhang (Author), Bin Wang (Author), Xi Chen (Author), Peng Lin (Author), Yu-Meng Zhu (Author), Zhi-Chuan Sun (Author), Ya-Zhou Wang (Author), Jian-Li Jiang (Author), Ling Li (Author), Xiang-Min Yang (Author), Zhi-Nan Chen (Author)
Format:	Book
Published:	Elsevier, 2023-10-01T00:00:00Z.
Subjects:	article
Online Access:	Connect to this object online.
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Modulation of Morphine Analgesia, Antinociceptive Tolerance, and Mu-Opioid Receptor Binding by the Cannabinoid CB2 Receptor Agonist O-1966
by: Zachary W. Reichenbach, et al.
Published: (2022)

Morphine induces endocytosis of neuronal μ-opioid receptors through the sustained transfer of Gα subunits to RGSZ2 proteins
by: Garzón Javier, et al.
Published: (2007)

Effects of Intraperitoneal and Intrathecal Morphine Analgesia on the Expression of μ-Opioid Receptors in Bone Cancer Pain Rats
by: Wei Liu, et al.
Published: (2019)

Microglia in morphine tolerance: cellular and molecular mechanisms and therapeutic potential
by: Xiangning Zhang, et al.
Published: (2024)

The distinct role of kappa opioid receptor in attenuating relapse to morphine/methamphetamine (polydrug) dependence in mice
by: Irna Elina Ridzwan, et al.
Published: (2018)

Disability of Development of Tolerance to Morphine and U-50,488H, a Selective κ-Opioid Receptor Agonist, in Neuropathic Pain Model Mice
by: Sourisak Sounvoravong, et al.
Published: (2004)

Morphine stimulates cervical cancer cells and alleviates cytotoxicity of chemotherapeutic drugs via opioid receptor‐dependent and ‐independent mechanisms
by: Zhengwen Yu, et al.
Published: (2022)

Gz mediates the long-lasting desensitization of brain CB1 receptors and is essential for cross-tolerance with morphine
by: Rodríguez-Muñoz María, et al.
Published: (2009)

Nitro-benzylideneoxymorphone, a bifunctional mu and delta opioid receptor ligand with high mu opioid receptor efficacy
by: Keith M. Olson, et al.
Published: (2023)

Potential Involvement of μ-Opioid Receptor Dysregulation on the Reduced Antinociception of Morphine in the Inflammatory Pain State in Mice
by: Yuta Aoki, et al.
Published: (2014)

Caenorhabditis Elegans Exhibits Morphine Addiction-like Behavior via the Opioid-like Receptor NPR-17
by: Soichiro Ide, et al.
Published: (2022)

Attenuation of morphine tolerance and dependence by thymoquinone in mice
by: Hossein Hosseinzadeh, et al.
Published: (2016)

Effects of valsartan on morphine tolerance and dependence in rats
by: Ayat Kaeidi, et al.
Published: (2021)

Spinal TLR4/P2X7 Receptor-Dependent NLRP3 Inflammasome Activation Contributes to the Development of Tolerance to Morphine-Induced Antinociception
by: Wang H, et al.
Published: (2020)

Postoperative analgesia with epidural opioids after cesarean section: Comparison of sufentanil, morphine and sufentanil-morphine combination
by: Kalpana S Vora, et al.
Published: (2012)

Effect of NLRP3 inflammasome induced astrocyte phenotype alteration in morphine tolerance
by: Zhenyu Yuan, et al.
Published: (2024)

Glucocorticoid Is Involved in Food-Entrainable Rhythm of μ-Opioid Receptor Expression in Mouse Brainstem and Analgesic Effect of Morphine
by: Yoshida Miyako, et al.
Published: (2006)

Oral morphine induces spinal 5‐hydroxytryptamine (5‐HT) release using an opioid receptor‐independent mechanism
by: Shingo Nakamura, et al.
Published: (2023)

Mu-opioid receptor expression in multibacillary leprosy
by: Patrícia Elizabeth Pignataro, et al.
Published: (2019)

Morphine Addiction and Oxidative Stress: The Potential Effects of Thioredoxin-1
by: Xian-Si Zeng, et al.
Published: (2020)

The effect of metformin on morphine analgesic tolerance and dependence in rats
by: Iman Fatemi, et al.
Published: (2018)

The N-Methyl-D-aspartate Receptor Antagonist Dizocilpine Inhibits Associative Antinociceptive Tolerance to Morphine in Mice: Relation With Memory
by: Mototaka Nakama-Kitamura
Published: (2005)

Potentiation of Morphine Analgesia by Adjuvant Activation of 5-HT7 Receptors
by: Alex Brenchat, et al.
Published: (2011)

A Comparison of Morphine Delivery in Neonatal Opioid Withdrawal
by: Brian Chisamore, et al.
Published: (2016)

A Comparison of Morphine Delivery in Neonatal Opioid Withdrawal
by: Brian Chisamore, et al.
Published: (2016)

Inhibition of Histone Deacetylases Attenuates Morphine Tolerance and Restores MOR Expression in the DRG of BCP Rats
by: Xiao-Tao He, et al.
Published: (2018)

The Influence of Contextual Cue on Antinociceptive Tolerance and Facilitation of Memory With Morphine
by: Mototaka Nakama-Kitamura, et al.
Published: (2003)

Opioid and GABAB receptors differentially couple to an adenylyl cyclase/protein kinase A downstream effector after chronic morphine treatment.
by: Elena Elizabeth Bagley
Published: (2014)

Peripheral effects of morphine and expression of μ-opioid receptors in the dorsal root ganglia during neuropathic pain: nitric oxide signaling
by: Pol Olga, et al.
Published: (2011)

Tapentadol shows lower intrinsic efficacy at µ receptor than morphine and oxycodone
by: Preeti Manandhar, et al.
Published: (2022)

Modulation by Sigma-1 Receptor of Morphine Analgesia and Tolerance: Nociceptive Pain, Tactile Allodynia and Grip Strength Deficits During Joint Inflammation
by: Ángeles Montilla-García, et al.
Published: (2019)

Mu Opioid Receptor Heterodimers Emerge as Novel Therapeutic Targets: Recent Progress and Future Perspective
by: Li Zhang, et al.
Published: (2020)

Functional selectivity of EM-2 analogs at the mu-opioid receptor
by: Justyna Piekielna-Ciesielska, et al.
Published: (2023)

Heteromerization Modulates mu Opioid Receptor Functional Properties in vivo
by: Muzeyyen Ugur, et al.
Published: (2018)

The standardized Withania somnifera Dunal root extract alters basal and morphine-induced opioid receptor gene expression changes in neuroblastoma cells
by: Francesca Felicia Caputi, et al.
Published: (2018)

Tyrosine 7.43 is important for mu-opioid receptor downstream signaling pathways activated by fentanyl
by: Xiangyun Tian, et al.
Published: (2022)

Studies on a novel regimen for management of orofacial pain and morphine tolerance
by: Yu-Hsien Lee, et al.
Published: (2018)

Experimental assessment of ladasten and GB-115 effects on the antinociceptive tolerance to morphine
by: M. A. Konstantinopolsky, et al.
Published: (2016)

The Extract of <i>Corydalis yanhusuo</i> Prevents Morphine Tolerance and Dependence
by: Lamees Alhassen, et al.
Published: (2021)

Crosstalk between G protein-coupled receptors (GPCRs) and tyrosine kinase receptor (TXR) in the heart after morphine withdrawal
by: Pilar eAlmela, et al.
Published: (2013)