XML-GBM lung: An explainable machine learning-based application for the diagnosis of lung cancer

• Main Authors: Sarreha Tasmin Rikta (Author), Khandaker Mohammad Mohi Uddin (Author), Nitish Biswas (Author), Rafid Mostafiz (Author), Fateha Sharmin (Author), Samrat Kumar Dey (Author)
• Format: Book
• Published: Elsevier, 2023-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.
• Notes: 2153-3539; 10.1016/j.jpi.2023.100307
• Keywords: Lung cancer; Explainable machine learning; ROS; SHAP; GBM; Mobile app; Computer applications to medicine. Medical informatics; R858-859.7; Pathology; RB1-214
• Source: Journal of Pathology Informatics, Vol 14, Iss , Pp 100307- (2023)

Lung cancer has been the leading cause of cancer-related deaths worldwide. Early detection and diagnosis of lung cancer can greatly improve the chances of survival for patients. Machine learning has been increasingly used in the medical sector for the detection of lung cancer, but the lack of interpretability of these models remains a significant challenge. Explainable machine learning (XML) is a new approach that aims to provide transparency and interpretability for machine learning models. The entire experiment has been performed in the lung cancer dataset obtained from Kaggle. The outcome of the predictive model with ROS (Random Oversampling) class balancing technique is used to comprehend the most relevant clinical features that contributed to the prediction of lung cancer using a machine learning explainable technique termed SHAP (SHapley Additive exPlanation). The results show the robustness of GBM's capacity to detect lung cancer, with 98.76% accuracy, 98.79% precision, 98.76% recall, 98.76% F-Measure, and 0.16% error rate, respectively. Finally, a mobile app is developed incorporating the best model to show the efficacy of our approach.