Hedgehog Pathway Inhibition Hampers Sphere and Holoclone Formation in Rhabdomyosarcoma

• Main Authors: Ana Almazán-Moga (Author), Patricia Zarzosa (Author), Isaac Vidal (Author), Carla Molist (Author), Irina Giralt (Author), Natalia Navarro (Author), Aroa Soriano (Author), Miguel F. Segura (Author), Arantza Alfranca (Author), Javier Garcia-Castro (Author), José Sánchez de Toledo (Author), Josep Roma (Author), Soledad Gallego (Author)
• Format: Book
• Published: Hindawi Limited, 2017-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Rhabdomyosarcoma (RMS) is the most common type of soft tissue sarcoma in children and can be divided into two main subtypes: embryonal (eRMS) and alveolar (aRMS). Among the cellular heterogeneity of tumors, the existence of a small fraction of cells called cancer stem cells (CSC), thought to be resp...