Formulation Development of Fluconazole-Loaded Lactose Agglomerate Tablets as a Disinfectant for <i>Candida</i>-Associated Dentures

• Main Authors: Rapee Jarungsirawat (Author), Wanassnant Kajthunyakarn (Author), Chaipat Siriwachirachai (Author), Thaned Pongjanyakul (Author)
• Format: Book
• Published: MDPI AG, 2022-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

Denture stomatitis is induced by irritation or an inflammatory response when wearing a denture for a long time. <i>Candida</i> species are the leading cause of biofilm formation on the surfaces and fissures of dentures. Thus, this study aimed to formulate and evaluate fluconazole tablets for use in preparing a disinfectant mixture with anticandidal activity. For size enlargement of lactose, a tablet diluent, using polyvinylpyrrolidone (PVP) as an agglomerating agent, was developed to enhance the flowability and compactability of the tablet preparation using direct compression. Lactose agglomerates with 6% PVP were used as a diluent for the fluconazole tablets. Furthermore, other excipients were used, such as a buffering agent, disintegrant, surfactant, and lubricant. The fluconazole tablets obtained could be dispersed and dissolved within 10 min in distilled water to achieve a clear mixture, providing a neutral pH and 96% transmittance. Furthermore, the fluconazole mixtures displayed anticandidal efficiency against <i>C. albicans</i> with a similar effect to the standard fluconazole solution. These findings suggest that the fluconazole-loaded lactose agglomerate tablets show strong potential when prepared using direct compression. The fluconazole mixtures made by dispersing the tablets can be used as a disinfectant for <i>Candida</i>-associated dentures, particularly in patients with oral candidiasis.

Item Description

10.3390/pharmaceutics14081723
1999-4923