Bruno-3 regulates sarcomere component expression and contributes to muscle phenotypes of myotonic dystrophy type 1

• Main Authors: Lucie Picchio (Author), Vincent Legagneux (Author), Stephane Deschamps (Author), Yoan Renaud (Author), Sabine Chauveau (Author), Luc Paillard (Author), Krzysztof Jagla (Author)
• Format: Book
• Published: The Company of Biologists, 2018-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Steinert disease, or myotonic dystrophy type 1 (DM1), is a multisystemic disorder caused by toxic noncoding CUG repeat transcripts, leading to altered levels of two RNA binding factors, MBNL1 and CELF1. The contribution of CELF1 to DM1 phenotypes is controversial. Here, we show that the Drosophila C...