MiR-219a-5p Enriched Extracellular Vesicles Induce OPC Differentiation and EAE Improvement More Efficiently Than Liposomes and Polymeric Nanoparticles

• Main Authors: Iñaki Osorio-Querejeta (Author), Susana Carregal-Romero (Author), Ana Ayerdi-Izquierdo (Author), Imre Mäger (Author), Leslie A. Nash (Author), Matthew Wood (Author), Ander Egimendia (Author), M. Betanzos (Author), Ainhoa Alberro (Author), Leire Iparraguirre (Author), Laura Moles (Author), Irantzu Llarena (Author), Marco Möller (Author), Felipe Goñi- (Author), Goran Bijelic (Author), Pedro Ramos-Cabrer (Author), Maider Muñoz-Culla (Author), David Otaegui (Author)
• Format: Book
• Published: MDPI AG, 2020-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Remyelination is a key aspect in multiple sclerosis pathology and a special effort is being made to promote it. However, there is still no available treatment to regenerate myelin and several strategies are being scrutinized. Myelination is naturally performed by oligodendrocytes and microRNAs have...