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Aptamer-based factor IXa inhibition preserves hemostasis and prevents thrombosis in a piglet model of ECMO

Extracorporeal membrane oxygenation (ECMO) requires anticoagulation to prevent clotting when the patient's blood contacts the circuit. Unfractionated heparin (UFH) usually prevents clotting but can cause life-threatening bleeding. An anticoagulant that selectively inhibits the contact activatio...

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Main Authors: Christopher R. Reed (Author), Desiree Bonadonna (Author), James C. Otto (Author), Charles Griffin McDaniel (Author), Charlene Vongai Chabata (Author), Maragatha Kuchibhatla (Author), James Frederiksen (Author), Juliana M. Layzer (Author), Gowthami M. Arepally (Author), Bruce A. Sullenger (Author), Elisabeth T. Tracy (Author)
Format: Book
Published: Elsevier, 2022-03-01T00:00:00Z.
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