Antidepressants have Anti-inflammatory Effects that may be Relevant to Dermatology: A Systematic Review

• Váldodahkkit: Shirin Eskeland (Dahkki), Jon Anders Halvorsen (Dahkki), Lars Tanum (Dahkki)
• Materiálatiipa: Girji
• Almmustuhtton: Medical Journals Sweden, 2017-07-01T00:00:00Z.
• Fáttát: article
• Liŋkkat: Connect to this object online.
• Notes: 0001-5555; 1651-2057; 10.2340/00015555-2702
• Keywords: systematicreview; antidepressant; dermatologicaldisorder; anti-depressive; anti-inflammatory; Dermatology; RL1-803
• Source: Acta Dermato-Venereologica, Vol 97, Iss 8, Pp 897-905 (2017)

There is increasing evidence of clinically relevant anti-inflammatory effects of monoaminergic antidepressants. PubMed and Ovid databases were searched systematically for the use and efficacy of antidepressants in association with 5 common inflammatory skin disorders: chronic urticaria, psoriasis, atopic dermatitis, other eczema, and alopecia areata. From January 1984 to June 2016, publications included a total of 1,252 dermatological patients in 28 trials or case reports. These unambiguously reported a reduced burden of dermatological symptoms in relation to treatment with antidepressants. Several randomized controlled trials of first-generation antidepressants have been published, while studies of modern antidepressants are usually open-label, yet more informative, regarding patients' characteristics and study procedures. These overall positive findings may indicate a rationale, beyond treating comorbid psychiatric disorders, for the use of antidepressants in dermatology. Further research into modern tolerable antidepressants, including selective serotonin re-uptake inhibitors, mirtazapine and bupropion, is required.