Ribosomopathies: how a common root can cause a tree of pathologies

• Ngā kaituhi matua: Nadia Danilova (Author), Hanna T. Gazda (Author)
• Hōputu: Pukapuka
• I whakaputaina: The Company of Biologists, 2015-09-01T00:00:00Z.
• Ngā marau: article
• Urunga tuihono: Connect to this object online.

Defects in ribosome biogenesis are associated with a group of diseases called the ribosomopathies, of which Diamond-Blackfan anemia (DBA) is the most studied. Ribosomes are composed of ribosomal proteins (RPs) and ribosomal RNA (rRNA). RPs and multiple other factors are necessary for the processing...