Design, synthesis and evaluation of a series of potential prodrugs of a Bruton's tyrosine kinase (BTK) inhibitor

BTK has become a particularly attractive therapeutic target in autoimmune diseases and B-cell malignancies, making BTK inhibitors a valuable and important therapeutic option. We present the design, synthesis, and evaluation of a series of prodrugs of a BTK inhibitor with an insoluble 2,5-diaminopyri...

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Main Authors: Zhou-Peng Xiao (Author), Min Liao (Author), Xue-Juan Huang (Author), Yu-Tong Wang (Author), Xiao-Cui Lan (Author), Xue-Ying Wang (Author), Xi-Tao Li (Author)
Format: Book
Published: Frontiers Media S.A., 2023-03-01T00:00:00Z.
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