Self-transfecting GMO-PMO chimera targeting Nanog enable gene silencing in vitro and suppresses tumor growth in 4T1 allografts in mouse

• Main Authors: Ujjal Das (Author), Jayanta Kundu (Author), Pallab Shaw (Author), Chandra Bose (Author), Atanu Ghosh (Author), Shalini Gupta (Author), Sudipta Sarkar (Author), Jhuma Bhadra (Author), Surajit Sinha (Author)
• Format: Book
• Published: Elsevier, 2023-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Phosphorodiamidate morpholino oligonucleotide (PMO)-based antisense reagents cannot enter cells without the help of a delivery technique, which limits their clinical applications. To overcome this problem, self-transfecting guanidinium-linked morpholino (GMO)-PMO or PMO-GMO chimeras have been explor...