Defective autophagy in Sf1 neurons perturbs the metabolic response to fasting and causes mitochondrial dysfunction

• Main Authors: Bérengère Coupé (Author), Corinne Leloup (Author), Kwame Asiedu (Author), Julien Maillard (Author), Luc Pénicaud (Author), Tamas L. Horvath (Author), Sebastien G. Bouret (Author)
• Format: Book
• Published: Elsevier, 2021-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: The ventromedial nucleus of the hypothalamus (VMH) is a critical component of the forebrain pathways that regulate energy homeostasis. It also plays an important role in the metabolic response to fasting. However, the mechanisms contributing to these physiological processes remain elusive...