Levofloxacin: Insights Into Antibiotic Resistance and Product Quality
Counterfeit and substandard medicines are recognized as one of serious threats to public health. The product quality of antibacterial medicine will compromise patients' recovery and increase the chance of antibacterial resistance. The review aims to provide a summary of low quality levofloxacin...
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Frontiers Media S.A.,
2019-08-01T00:00:00Z.
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| 100 | 1 | 0 | |a Ensieh Izadi |e author |
| 700 | 1 | 0 | |a Gull Afshan |e author |
| 700 | 1 | 0 | |a Rahul P. Patel |e author |
| 700 | 1 | 0 | |a Venkatesan M. Rao |e author |
| 700 | 1 | 0 | |a Kai Bin Liew |e author |
| 700 | 1 | 0 | |a Meor Mohd Redzuan Meor Mohd Affandi |e author |
| 700 | 1 | 0 | |a Nurolaini Kifli |e author |
| 700 | 1 | 0 | |a Amal Suleiman |e author |
| 700 | 1 | 0 | |a Kah Seng Lee |e author |
| 700 | 1 | 0 | |a Md. Moklesur R. Sarker |e author |
| 700 | 1 | 0 | |a Syed Tabish Zaidi |e author |
| 700 | 1 | 0 | |a Syed Tabish Zaidi |e author |
| 700 | 1 | 0 | |a Long Chiau Ming |e author |
| 700 | 1 | 0 | |a Long Chiau Ming |e author |
| 245 | 0 | 0 | |a Levofloxacin: Insights Into Antibiotic Resistance and Product Quality |
| 260 | |b Frontiers Media S.A., |c 2019-08-01T00:00:00Z. | ||
| 500 | |a 1663-9812 | ||
| 500 | |a 10.3389/fphar.2019.00881 | ||
| 520 | |a Counterfeit and substandard medicines are recognized as one of serious threats to public health. The product quality of antibacterial medicine will compromise patients' recovery and increase the chance of antibacterial resistance. The review aims to provide a summary of low quality levofloxacin issues and the risk factors as well as suggesting the aspects of product quality that need to be regulated strictly. Quality of the active ingredient, levofloxacin, has an important role to contribute to successful therapy. The poor quality of raw material, directly and indirectly, causes treatment failure as the presence of insufficient dose, mislabeled content, and poor dissolution characteristics can lead to lower bioavailability. Identifying and reporting these factors can potentially help in improving the quality of drug marketed in various developing countries and may also reduce the incidences of treatment failure. Dissolution test is used for testing the dissolution profiles and the rate of drug release from solid formulation such as oral formulations, thus providing information regarding the in vivo performance of a formulation and its bioequivalence. On the other hand, quality-testing procedures are used for comparing the quality of products. | ||
| 546 | |a EN | ||
| 690 | |a counterfeit | ||
| 690 | |a post marketing surveillance | ||
| 690 | |a regulatory requirement | ||
| 690 | |a fluroquinolone resistance | ||
| 690 | |a quality medicine | ||
| 690 | |a Therapeutics. Pharmacology | ||
| 690 | |a RM1-950 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Frontiers in Pharmacology, Vol 10 (2019) | |
| 787 | 0 | |n https://www.frontiersin.org/article/10.3389/fphar.2019.00881/full | |
| 787 | 0 | |n https://doaj.org/toc/1663-9812 | |
| 856 | 4 | 1 | |u https://doaj.org/article/d7ea7fcdde5e498ca1c9905a7dd709f5 |z Connect to this object online. |