Synthesis and study of antimicrobial activity of some tetrahydrocarbazole derivatives substituted with NSAID
New tetrahydrocarbazole derivatives substituted at the heteroatom (N) by non-steroidal anti-inflammatory drug (NSAIDs) were synthesized by reaction of cyclohehexanon (C.H.N.) with phenyl hydrazine (P.H.Z.) to form tetrahydrocarbazole (THCZ), where the latter is reacted with NSAID (Ketoprofen) via am...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Book |
| Published: |
College of Pharmacy / Mustansiriyah University,
2022-06-01T00:00:00Z.
|
| Subjects: | |
| Online Access: | Connect to this object online. |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | New tetrahydrocarbazole derivatives substituted at the heteroatom (N) by non-steroidal anti-inflammatory drug (NSAIDs) were synthesized by reaction of cyclohehexanon (C.H.N.) with phenyl hydrazine (P.H.Z.) to form tetrahydrocarbazole (THCZ), where the latter is reacted with NSAID (Ketoprofen) via amide bond to yield substituted THCZ, compounds chemical structures were verified by: 1H, 13C NMR and FTIR spectroscopy. Antifungal activity of the synthesized compounds was investigated by docking study and in vitro test to reveal good antifungal activity, but the in vitro test also showed that the compounds have weak to moderate antibacterial activity. |
|---|---|
| Item Description: | 10.32947/ajps.v22i2.857 1815-0993 2959-183X |