Blockade of Leukotriene B4 Signaling Pathway Induces Apoptosis and Suppresses Cell Proliferation in Colon Cancer

• Hlavní autoři: Aya Ihara (Autor), Koichiro Wada (Autor), Masato Yoneda (Autor), Nobutaka Fujisawa (Autor), Hirokazu Takahashi (Autor), Atsushi Nakajima (Autor)
• Médium: Kniha
• Vydáno: Elsevier, 2007-01-01T00:00:00Z.
• Témata: article
• On-line přístup: Connect to this object online.

We investigated whether leukotriene B4 (LTB4) and its signaling pathway play an important role in the progression of human colon cancer via a direct stimulation of cancer cell proliferation. Remarkable expression of LTB4 receptor 1 (BLT1) in human colon cancer tissues was detected by immunohistochem...