Blockade of Leukotriene B4 Signaling Pathway Induces Apoptosis and Suppresses Cell Proliferation in Colon Cancer

• Egile Nagusiak: Aya Ihara (Egilea), Koichiro Wada (Egilea), Masato Yoneda (Egilea), Nobutaka Fujisawa (Egilea), Hirokazu Takahashi (Egilea), Atsushi Nakajima (Egilea)
• Formatua: Liburua
• Argitaratua: Elsevier, 2007-01-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

We investigated whether leukotriene B4 (LTB4) and its signaling pathway play an important role in the progression of human colon cancer via a direct stimulation of cancer cell proliferation. Remarkable expression of LTB4 receptor 1 (BLT1) in human colon cancer tissues was detected by immunohistochem...