Blockade of Leukotriene B4 Signaling Pathway Induces Apoptosis and Suppresses Cell Proliferation in Colon Cancer

• Autori principali: Aya Ihara (Autore), Koichiro Wada (Autore), Masato Yoneda (Autore), Nobutaka Fujisawa (Autore), Hirokazu Takahashi (Autore), Atsushi Nakajima (Autore)
• Natura: Libro
• Pubblicazione: Elsevier, 2007-01-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

We investigated whether leukotriene B4 (LTB4) and its signaling pathway play an important role in the progression of human colon cancer via a direct stimulation of cancer cell proliferation. Remarkable expression of LTB4 receptor 1 (BLT1) in human colon cancer tissues was detected by immunohistochem...