Blockade of Leukotriene B4 Signaling Pathway Induces Apoptosis and Suppresses Cell Proliferation in Colon Cancer

• 主要な著者: Aya Ihara (著者), Koichiro Wada (著者), Masato Yoneda (著者), Nobutaka Fujisawa (著者), Hirokazu Takahashi (著者), Atsushi Nakajima (著者)
• フォーマット: 図書
• 出版事項: Elsevier, 2007-01-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

We investigated whether leukotriene B4 (LTB4) and its signaling pathway play an important role in the progression of human colon cancer via a direct stimulation of cancer cell proliferation. Remarkable expression of LTB4 receptor 1 (BLT1) in human colon cancer tissues was detected by immunohistochem...