Blockade of Leukotriene B4 Signaling Pathway Induces Apoptosis and Suppresses Cell Proliferation in Colon Cancer

• Главные авторы: Aya Ihara (Автор), Koichiro Wada (Автор), Masato Yoneda (Автор), Nobutaka Fujisawa (Автор), Hirokazu Takahashi (Автор), Atsushi Nakajima (Автор)
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• Опубликовано: Elsevier, 2007-01-01T00:00:00Z.
• Предметы: article
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We investigated whether leukotriene B4 (LTB4) and its signaling pathway play an important role in the progression of human colon cancer via a direct stimulation of cancer cell proliferation. Remarkable expression of LTB4 receptor 1 (BLT1) in human colon cancer tissues was detected by immunohistochem...