Targeting PYK2, entrectinib allays anterior subcapsular cataracts in mice by regulating TGFβ2 signaling pathway

• Main Authors: Xuefei Ding (Author), Xiaohe Li (Author), Rui Fang (Author), Peilin Yue (Author), Yuxuan Jia (Author), Enjie Li (Author), Yayue Hu (Author), Honggang Zhou (Author), Xudong Song (Author)
• Format: Book
• Published: BMC, 2024-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Fibrosis cataract occurs in patients receiving cataract extraction. Still, no medication that can cure the disease exists in clinical. This study aims to investigate the effects and mechanisms of Entrectinib on fibrotic cataract in vitro and in vivo. Methods The human lens cells...