Forefront of Na+/Ca2+ Exchanger Studies: Regulation Kinetics of Na+/Ca2+ Exchangers
Five isoforms of Na+/Ca2+ exchanger have been identified: NCX1, NCX2, NCX3, NCX-SQ1, and CALX. In all of the exchangers, the Na+/Ca2+ exchange current, which was recorded in inside-out membrane patches, was regulated by cytoplasmic Ca2+. However, the mode of regulation is different among the exchang...
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| Format: | Book |
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Elsevier,
2004-01-01T00:00:00Z.
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| Summary: | Five isoforms of Na+/Ca2+ exchanger have been identified: NCX1, NCX2, NCX3, NCX-SQ1, and CALX. In all of the exchangers, the Na+/Ca2+ exchange current, which was recorded in inside-out membrane patches, was regulated by cytoplasmic Ca2+. However, the mode of regulation is different among the exchangers. NCX1, NCX2, and NCX-SQ1 are positively regulated by cytoplasmic Ca2+, but CALX is negatively regulated. NCX3 apparently has both positive and negative regulation mechanisms. In this review, I briefly summarize the Ca2+-dependent regulation mechanisms of the exchangers. Keywords:: Na+/Ca2+ exchanger (NCX), transporter, regulation, patch clamp |
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| Item Description: | 1347-8613 10.1254/jphs.fmj04002x2 |