Effect of walnut oligopeptideson on digestive function-related gastric secretions and blood/serum indicators in rats and on small intestinal propulsion in mice

ObjectiveTo investigate the effect of walnut oligopeptides (WOPs) on digestive function-related gastric secretion and blood/serum indicators in rats and on small intestinal propulsion in mice.MethodsTotally 130 male Sprague-Dawley (SD) rats and 70 male ICR mice were included in the study. The SD rat...

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Main Authors: Rui LIU (Author), Yuntao HAO (Author), Xinran LIU (Author), Na ZHU (Author), Jiani HU (Author), Jiawei KANG (Author), Ruixue MAO (Author), Yong LI (Author)
Format: Book
Published: Editorial Office of Chinese Journal of Public Health, 2024-01-01T00:00:00Z.
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LEADER 00000 am a22000003u 4500
001 doaj_d8f24a25a3844abf8e7ed09e274c68db
042 |a dc 
100 1 0 |a Rui LIU  |e author 
700 1 0 |a Yuntao HAO  |e author 
700 1 0 |a Xinran LIU  |e author 
700 1 0 |a Na ZHU  |e author 
700 1 0 |a Jiani HU  |e author 
700 1 0 |a Jiawei KANG  |e author 
700 1 0 |a Ruixue MAO  |e author 
700 1 0 |a Yong LI  |e author 
245 0 0 |a Effect of walnut oligopeptideson on digestive function-related gastric secretions and blood/serum indicators in rats and on small intestinal propulsion in mice 
260 |b Editorial Office of Chinese Journal of Public Health,   |c 2024-01-01T00:00:00Z. 
500 |a 1001-0580 
500 |a 10.11847/zgggws1141977 
520 |a ObjectiveTo investigate the effect of walnut oligopeptides (WOPs) on digestive function-related gastric secretion and blood/serum indicators in rats and on small intestinal propulsion in mice.MethodsTotally 130 male Sprague-Dawley (SD) rats and 70 male ICR mice were included in the study. The SD rats were first randomly divided into two subgroups (70 in subgroup Ⅰ and 60 in subgroup Ⅱ). The 70 SD rats of subgroup I and the 70 ICR mice were then randomly assigned into three control groups (normal, model, and whey protein control), three WOPs treatment groups (at dosages of 220, 440 and 880 mg/kg·bw), and a WOPs plus bovine collagen oligopeptides (BCOPs), with 10 rats or mice in each group respectively. The group-specific treatment was conclucted by intragastric administration of once a day for 30 days for the rats and 7 days for the mice; the grouping and treatments in 60 SD rats of subgroup II were the same as those of subgroup I, except for the absence of model control group. By the end of the treatments, the rats of subgroup I underwent pyloric ligation and collection of gastric fluid for detecting gastric acid and gastric tissue pepsin and serum gastrointestinal-associated regulatory hormones were also measured; while, the rats of subgroup II had choledochal cannula for bile collection. After 7-day's treatment, the mice had another gavage of loperamide hydrochloride for examination of small intestinal propulsive function. ResultsCompared with those in the model control group, the free acid, total acid and total acid excretion of gastric juice were significantly higher and the pepsin activity was significantly lower in the WOPs dose groups (all P < 0.05). The content of growth inhibitory hormone in high WOPs dose (880 mg/kg·bw) group was significantly lower than that in the model control group; the rats with medium (440 mg/kg·bw) and high (880 mg/kg·bw) WOPs treatment and combined treatment of WOPs and BCOPs had significantly higher motilin, substance P, and gastrin than those in the rats of model control group. The small intestinal propulsion rates of the mice in WOPs dose groups were significantly higher than that of model control mice (P < 0.05 for all). ConclusionWOPs can exert pro-digestive effect by regulating the secretions of gastric acid, pepsin, gastrointestinal hormone in rats and by promoting gastrointestinal peristalsis in mice. 
546 |a ZH 
690 |a walnut oligopeptides 
690 |a digestive function 
690 |a pepsin 
690 |a gastrointestinal hormone 
690 |a Public aspects of medicine 
690 |a RA1-1270 
655 7 |a article  |2 local 
786 0 |n Zhongguo gonggong weisheng, Vol 40, Iss 1, Pp 50-56 (2024) 
787 0 |n https://www.zgggws.com/article/doi/10.11847/zgggws1141977 
787 0 |n https://doaj.org/toc/1001-0580 
856 4 1 |u https://doaj.org/article/d8f24a25a3844abf8e7ed09e274c68db  |z Connect to this object online.