Discovery of New Potent anti-MERS CoV Fusion Inhibitors

• Ngā kaituhi matua: Mahmoud Kandeel (Author), Mizuki Yamamoto (Author), Byoung Kwon Park (Author), Abdulla Al-Taher (Author), Aya Watanabe (Author), Jin Gohda (Author), Yasushi Kawaguchi (Author), Kentaro Oh-hashi (Author), Hyung-Joo Kwon (Author), Jun-ichiro Inoue (Author)
• Hōputu: Pukapuka
• I whakaputaina: Frontiers Media S.A., 2021-06-01T00:00:00Z.
• Ngā marau: article
• Urunga tuihono: Connect to this object online.

Middle East respiratory syndrome coronavirus (MERS-CoV), capable of zoonotic transmission, has been associated with emerging viral pneumonia in humans. In this study, a set of highly potent peptides were designed to prevent MERS-CoV fusion through competition with heptad repeat domain 2 (HR2) at its...