Discovery of New Potent anti-MERS CoV Fusion Inhibitors

• Главные авторы: Mahmoud Kandeel (Автор), Mizuki Yamamoto (Автор), Byoung Kwon Park (Автор), Abdulla Al-Taher (Автор), Aya Watanabe (Автор), Jin Gohda (Автор), Yasushi Kawaguchi (Автор), Kentaro Oh-hashi (Автор), Hyung-Joo Kwon (Автор), Jun-ichiro Inoue (Автор)
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• Опубликовано: Frontiers Media S.A., 2021-06-01T00:00:00Z.
• Предметы: article
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Middle East respiratory syndrome coronavirus (MERS-CoV), capable of zoonotic transmission, has been associated with emerging viral pneumonia in humans. In this study, a set of highly potent peptides were designed to prevent MERS-CoV fusion through competition with heptad repeat domain 2 (HR2) at its...