Towards genomic medicine: a tailored next-generation sequencing panel for hydroxyurea pharmacogenomics in Tanzania

• Main Authors: Siana Nkya (Author), Collin Nzunda (Author), Emmanuel Saukiwa (Author), Frida Kaywanga (Author), Eliud Buberwa (Author), David Solomon (Author), Heavenlight Christopher (Author), Doreen Ngowi (Author), Julieth Johansen (Author), Florence Urio (Author), Josephine Mgaya (Author), Salman Karim (Author), Mohamed Zahir Alimohamed (Author), Raphael Z. Sangeda (Author), Clara Chamba (Author), Emile R. Chimusa (Author), Enrico Novelli (Author), Julie Makani (Author)
• Format: Book
• Published: BMC, 2024-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Pharmacogenomics of hydroxyurea is an important aspect in the management of sickle cell disease (SCD), especially in the era of genomic medicine. Genetic variations in loci associated with HbF induction and drug metabolism are prime targets for hydroxyurea (HU) pharmacogenomics, ...