Anti-Inflammatory Effects of Ellagic Acid on Acute Lung Injury Induced by Acid in Mice

Acute lung injury (ALI) is characterized by alveolar edema and uncontrolled neutrophil migration to the lung, and no specific therapy is still available. Ellagic acid, a compound present in several fruits and medicinal plants, has shown anti-inflammatory activity in several experimental disease mode...

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Main Authors: Daniely Cornélio Favarin (Author), Maxelle Martins Teixeira (Author), Ednéia Lemos de Andrade (Author), Claudiney de Freitas Alves (Author), Javier Emilio Lazo Chica (Author), Carlos Artério Sorgi (Author), Lúcia Helena Faccioli (Author), Alexandre Paula Rogerio (Author)
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Published: Hindawi Limited, 2013-01-01T00:00:00Z.
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042 |a dc 
100 1 0 |a Daniely Cornélio Favarin  |e author 
700 1 0 |a Maxelle Martins Teixeira  |e author 
700 1 0 |a Ednéia Lemos de Andrade  |e author 
700 1 0 |a Claudiney de Freitas Alves  |e author 
700 1 0 |a Javier Emilio Lazo Chica  |e author 
700 1 0 |a Carlos Artério Sorgi  |e author 
700 1 0 |a Lúcia Helena Faccioli  |e author 
700 1 0 |a Alexandre Paula Rogerio  |e author 
245 0 0 |a Anti-Inflammatory Effects of Ellagic Acid on Acute Lung Injury Induced by Acid in Mice 
260 |b Hindawi Limited,   |c 2013-01-01T00:00:00Z. 
500 |a 0962-9351 
500 |a 1466-1861 
500 |a 10.1155/2013/164202 
520 |a Acute lung injury (ALI) is characterized by alveolar edema and uncontrolled neutrophil migration to the lung, and no specific therapy is still available. Ellagic acid, a compound present in several fruits and medicinal plants, has shown anti-inflammatory activity in several experimental disease models. We used the nonlethal acid aspiration model of ALI in mice to determine whether preventive or therapeutic administration of ellagic acid (10 mg/kg; oral route) could interfere with the development or establishment of ALI inflammation. Dexamethasone (1 mg/kg; subcutaneous route) was used as a positive control. In both preventive and therapeutic treatments, ellagic acid reduced the vascular permeability changes and neutrophil recruitment to the bronchoalveolar lavage fluid (BALF) and to lung compared to the vehicle. In addition, the ellagic acid accelerated the resolution for lung neutrophilia. Moreover, ellagic acid reduced the COX-2-induced exacerbation of inflammation. These results were similar to the dexamethasone. However, while the anti-inflammatory effects of dexamethasone treatment were due to the reduced activation of NF-κB and AP-1, the ellagic acid treatment led to reduced BALF levels of IL-6 and increased levels of IL-10. In addition, dexamethasone treatment reduced IL-1β. Together, these findings identify ellagic acid as a potential therapeutic agent for ALI-associated inflammation. 
546 |a EN 
690 |a Pathology 
690 |a RB1-214 
655 7 |a article  |2 local 
786 0 |n Mediators of Inflammation, Vol 2013 (2013) 
787 0 |n http://dx.doi.org/10.1155/2013/164202 
787 0 |n https://doaj.org/toc/0962-9351 
787 0 |n https://doaj.org/toc/1466-1861 
856 4 1 |u https://doaj.org/article/d93d3da5fd3c4930b1b5fa067d37a729  |z Connect to this object online.