Mycophenolic acid in Rheumatology: mechanisms of action and severe adverse events
MPA is clinically administered as morfolinoethyl ester (mycophenolate mofetil, MMF) or, more recently, as a salt (enteric-coated mycophenolate sodium). It is a fermentation product of Penicillium brevicompactum and other analogue fungi, identified by Gosio in 1893 as a weak antibacterial agent; in 1...
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| Main Authors: | , , |
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| Format: | Book |
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PAGEPress Publications,
2011-06-01T00:00:00Z.
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| Summary: | MPA is clinically administered as morfolinoethyl ester (mycophenolate mofetil, MMF) or, more recently, as a salt (enteric-coated mycophenolate sodium). It is a fermentation product of Penicillium brevicompactum and other analogue fungi, identified by Gosio in 1893 as a weak antibacterial agent; in 1969 Franklin and Cook discovered its capacity to inhibit the inosine mono phosphate dehydrogenase (IMPDH), an enzyme involved in purine nucleotide synthesis (1)... |
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| Item Description: | 10.4081/reumatismo.2010.91 0048-7449 2240-2683 |