Effects of Chronic Administration of Zonisamide, an Antiepileptic Drug, on Bone Mineral Density and Their Prevention With Alfacalcidol in Growing Rats

• Main Authors: Atsushi Takahashi (Author), Kenji Onodera (Author), Junzo Kamei (Author), Shinobu Sakurada (Author), Hisashi Shinoda (Author), Shuichi Miyazaki (Author), Takashi Saito (Author), Hideaki Mayanagi (Author)
• Format: Book
• Published: Elsevier, 2003-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We investigated the effects of chronic administration of zonisamide, an antiepileptic agent, on bone metabolism in growing rats. Administration of zonisamide at a dose of 80 mg/kg per day, s.c. for 5 weeks significantly decreased bone mineral density (BMD) at the tibial metaphysis and the diaphysis....