Hydrogen Sulfide Causes Relaxation in Mouse Bronchial Smooth Muscle
We investigated the effects of NaHS, a hydrogen sulfide (H2S) donor, on the tension of isolated mouse and guinea-pig bronchial rings. NaHS at 0.01 - 10 mM had no effect on the tone of those preparations without precontraction. When the preparation was precontracted with carbachol, NaHS at 0.1 - 3 mM...
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Elsevier,
2007-01-01T00:00:00Z.
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| 001 | doaj_d9a62e66eee84090b1de5aab8982783f | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Satoko Kubo |e author |
| 700 | 1 | 0 | |a Ichiko Doe |e author |
| 700 | 1 | 0 | |a Yuko Kurokawa |e author |
| 700 | 1 | 0 | |a Atsufumi Kawabata |e author |
| 245 | 0 | 0 | |a Hydrogen Sulfide Causes Relaxation in Mouse Bronchial Smooth Muscle |
| 260 | |b Elsevier, |c 2007-01-01T00:00:00Z. | ||
| 500 | |a 1347-8613 | ||
| 500 | |a 10.1254/jphs.SC0070199 | ||
| 520 | |a We investigated the effects of NaHS, a hydrogen sulfide (H2S) donor, on the tension of isolated mouse and guinea-pig bronchial rings. NaHS at 0.01 - 10 mM had no effect on the tone of those preparations without precontraction. When the preparation was precontracted with carbachol, NaHS at 0.1 - 3 mM strongly relaxed the mouse rings, but produced only slight relaxation in the guinea-pig rings. The NaHS-induced relaxation in the mouse bronchus was resistant to inhibitors of ATP-sensitive K+ channels, soluble guanylyl cyclase, cyclooxygenase (COX)-1 or COX-2, and antagonists of tachykinin receptors. Thus, NaHS evokes bronchodilation in mice, suggesting a possible role for H2S in the respiratory system. Keywords:: hydrogen sulfide (H2S), smooth muscle, bronchodilation | ||
| 546 | |a EN | ||
| 690 | |a Therapeutics. Pharmacology | ||
| 690 | |a RM1-950 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Journal of Pharmacological Sciences, Vol 104, Iss 4, Pp 392-396 (2007) | |
| 787 | 0 | |n http://www.sciencedirect.com/science/article/pii/S1347861319342392 | |
| 787 | 0 | |n https://doaj.org/toc/1347-8613 | |
| 856 | 4 | 1 | |u https://doaj.org/article/d9a62e66eee84090b1de5aab8982783f |z Connect to this object online. |