Parasite-antigen driven expansion of IL-5(-) and IL-5(+) Th2 human subpopulations in lymphatic filariasis and their differential dependence on IL-10 and TGFβ.

<h4>Background</h4>Two different Th2 subsets have been defined recently on the basis of IL-5 expression - an IL-5(+)Th2 subset and an IL-5(-)Th2 subset in the setting of allergy. However, the role of these newly described CD4(+) T cells subpopulations has not been explored in other conte...

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Main Authors: Rajamanickam Anuradha (Author), Parakkal Jovvian George (Author), Luke E Hanna (Author), Vedachalam Chandrasekaran (Author), P Paul Kumaran (Author), Thomas B Nutman (Author), Subash Babu (Author)
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Published: Public Library of Science (PLoS), 2014-01-01T00:00:00Z.
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042 |a dc 
100 1 0 |a Rajamanickam Anuradha  |e author 
700 1 0 |a Parakkal Jovvian George  |e author 
700 1 0 |a Luke E Hanna  |e author 
700 1 0 |a Vedachalam Chandrasekaran  |e author 
700 1 0 |a P Paul Kumaran  |e author 
700 1 0 |a Thomas B Nutman  |e author 
700 1 0 |a Subash Babu  |e author 
245 0 0 |a Parasite-antigen driven expansion of IL-5(-) and IL-5(+) Th2 human subpopulations in lymphatic filariasis and their differential dependence on IL-10 and TGFβ. 
260 |b Public Library of Science (PLoS),   |c 2014-01-01T00:00:00Z. 
500 |a 1935-2727 
500 |a 1935-2735 
500 |a 10.1371/journal.pntd.0002658 
520 |a <h4>Background</h4>Two different Th2 subsets have been defined recently on the basis of IL-5 expression - an IL-5(+)Th2 subset and an IL-5(-)Th2 subset in the setting of allergy. However, the role of these newly described CD4(+) T cells subpopulations has not been explored in other contexts.<h4>Methods</h4>To study the role of the Th2 subpopulation in a chronic, tissue invasive parasitic infection (lymphatic filariasis), we examined the frequency of IL-5(+)IL-4(+)IL-13(+) CD4(+) T cells and IL-5(-)IL-4 IL-13(+) CD4(+) T cells in asymptomatic, infected individuals (INF) and compared them to frequencies (Fo) in filarial-uninfected (UN) individuals and to those with filarial lymphedema (CP).<h4>Results</h4>INF individuals exhibited a significant increase in the spontaneously expressed and antigen-induced Fo of both Th2 subpopulations compared to the UN and CP. Interestingly, there was a positive correlation between the Fo of IL-5(+)Th2 cells and the absolute eosinophil and neutrophil counts; in addition there was a positive correlation between the frequency of the CD4(+)IL-5(-)Th2 subpopulation and the levels of parasite antigen - specific IgE and IgG4 in INF individuals. Moreover, blockade of IL-10 and/or TGFβ demonstrated that each of these 2 regulatory cytokines exert opposite effects on the different Th2 subsets. Finally, in those INF individuals cured of infection by anti-filarial therapy, there was a significantly decreased Fo of both Th2 subsets.<h4>Conclusions</h4>Our findings suggest that both IL-5(+) and IL-5(-)Th2 cells play an important role in the regulation of immune responses in filarial infection and that these two Th2 subpopulations may be regulated by different cytokine-receptor mediated processes. 
546 |a EN 
690 |a Arctic medicine. Tropical medicine 
690 |a RC955-962 
690 |a Public aspects of medicine 
690 |a RA1-1270 
655 7 |a article  |2 local 
786 0 |n PLoS Neglected Tropical Diseases, Vol 8, Iss 1, p e2658 (2014) 
787 0 |n https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24498448/?tool=EBI 
787 0 |n https://doaj.org/toc/1935-2727 
787 0 |n https://doaj.org/toc/1935-2735 
856 4 1 |u https://doaj.org/article/da18b081ab5b4f7f918f568fb5dbcaa0  |z Connect to this object online.