Parasite-antigen driven expansion of IL-5(-) and IL-5(+) Th2 human subpopulations in lymphatic filariasis and their differential dependence on IL-10 and TGFβ.
<h4>Background</h4>Two different Th2 subsets have been defined recently on the basis of IL-5 expression - an IL-5(+)Th2 subset and an IL-5(-)Th2 subset in the setting of allergy. However, the role of these newly described CD4(+) T cells subpopulations has not been explored in other conte...
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2014-01-01T00:00:00Z.
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LEADER | 00000 am a22000003u 4500 | ||
---|---|---|---|
001 | doaj_da18b081ab5b4f7f918f568fb5dbcaa0 | ||
042 | |a dc | ||
100 | 1 | 0 | |a Rajamanickam Anuradha |e author |
700 | 1 | 0 | |a Parakkal Jovvian George |e author |
700 | 1 | 0 | |a Luke E Hanna |e author |
700 | 1 | 0 | |a Vedachalam Chandrasekaran |e author |
700 | 1 | 0 | |a P Paul Kumaran |e author |
700 | 1 | 0 | |a Thomas B Nutman |e author |
700 | 1 | 0 | |a Subash Babu |e author |
245 | 0 | 0 | |a Parasite-antigen driven expansion of IL-5(-) and IL-5(+) Th2 human subpopulations in lymphatic filariasis and their differential dependence on IL-10 and TGFβ. |
260 | |b Public Library of Science (PLoS), |c 2014-01-01T00:00:00Z. | ||
500 | |a 1935-2727 | ||
500 | |a 1935-2735 | ||
500 | |a 10.1371/journal.pntd.0002658 | ||
520 | |a <h4>Background</h4>Two different Th2 subsets have been defined recently on the basis of IL-5 expression - an IL-5(+)Th2 subset and an IL-5(-)Th2 subset in the setting of allergy. However, the role of these newly described CD4(+) T cells subpopulations has not been explored in other contexts.<h4>Methods</h4>To study the role of the Th2 subpopulation in a chronic, tissue invasive parasitic infection (lymphatic filariasis), we examined the frequency of IL-5(+)IL-4(+)IL-13(+) CD4(+) T cells and IL-5(-)IL-4 IL-13(+) CD4(+) T cells in asymptomatic, infected individuals (INF) and compared them to frequencies (Fo) in filarial-uninfected (UN) individuals and to those with filarial lymphedema (CP).<h4>Results</h4>INF individuals exhibited a significant increase in the spontaneously expressed and antigen-induced Fo of both Th2 subpopulations compared to the UN and CP. Interestingly, there was a positive correlation between the Fo of IL-5(+)Th2 cells and the absolute eosinophil and neutrophil counts; in addition there was a positive correlation between the frequency of the CD4(+)IL-5(-)Th2 subpopulation and the levels of parasite antigen - specific IgE and IgG4 in INF individuals. Moreover, blockade of IL-10 and/or TGFβ demonstrated that each of these 2 regulatory cytokines exert opposite effects on the different Th2 subsets. Finally, in those INF individuals cured of infection by anti-filarial therapy, there was a significantly decreased Fo of both Th2 subsets.<h4>Conclusions</h4>Our findings suggest that both IL-5(+) and IL-5(-)Th2 cells play an important role in the regulation of immune responses in filarial infection and that these two Th2 subpopulations may be regulated by different cytokine-receptor mediated processes. | ||
546 | |a EN | ||
690 | |a Arctic medicine. Tropical medicine | ||
690 | |a RC955-962 | ||
690 | |a Public aspects of medicine | ||
690 | |a RA1-1270 | ||
655 | 7 | |a article |2 local | |
786 | 0 | |n PLoS Neglected Tropical Diseases, Vol 8, Iss 1, p e2658 (2014) | |
787 | 0 | |n https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24498448/?tool=EBI | |
787 | 0 | |n https://doaj.org/toc/1935-2727 | |
787 | 0 | |n https://doaj.org/toc/1935-2735 | |
856 | 4 | 1 | |u https://doaj.org/article/da18b081ab5b4f7f918f568fb5dbcaa0 |z Connect to this object online. |