Endocrine therapy resistance: what we know and future directions

• मुख्य लेखकों: David Musheyev (लेखक), Anya Alayev (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Open Exploration Publishing Inc., 2022-08-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.
• Notes: 10.37349/etat.2022.00096; 2692-3114
• Keywords: endocrine resistance; estrogen receptor-positive; signaling crosstalk; Internal medicine; RC31-1245
• Source: Exploration of Targeted Anti-tumor Therapy, Vol 3, Iss 4, Pp 480-496 (2022)

Endocrine resistance is a major hurdle in the treatment of estrogen receptor (ER)-positive breast cancer. When abnormally regulated, molecular signals responsible for cellular proliferation, as well as ER itself, allow for cellular evasion of ER-dependent treatments. Therefore, pharmacological treatments that target these evasion mechanisms are beneficial for the treatment of endocrine-resistant breast cancers. This review summarizes currently understood molecular signals that contribute to endocrine resistance and their crosstalk that stem from mitogen-activated protein kinase (MAPK), phosphoinositol-3 kinase/protein kinase B (PI3K/AKT), mechanistic target of rapamycin (mTOR), cyclin-dependent kinases 4 and 6 (CDK4/6) and aberrant ER function. Recent clinical trials that target these molecular signals as a treatment strategy for endocrine-resistant breast cancer are also highlighted.