Why <span style="font-variant: small-caps">d</span>-Mannose May Be as Efficient as Antibiotics in the Treatment of Acute Uncomplicated Lower Urinary Tract Infections-Preliminary Considerations and Conclusions from a Non-Interventional Study

• Main Authors: Florian Wagenlehner (Author), Horst Lorenz (Author), Oda Ewald (Author), Peter Gerke (Author)
• Format: Book
• Published: MDPI AG, 2022-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

Urinary tract infections (UTIs) are very frequent in women and can be caused by a range of pathogens. High recurrence rates and increasing antibiotic resistance of uropathogens make UTIs a severe public health problem. <span style="font-variant: small-caps;">d</span>-mannose is a monosaccharide that can inhibit bacterial adhesion to the urothelium after oral intake. Several clinical studies have shown the efficacy of <span style="font-variant: small-caps;">d</span>-mannose in the prevention of recurrent UTIs; these also provided limited evidence for the efficacy of <span style="font-variant: small-caps;">d</span>-mannose in acute therapy. A recent prospective, non-interventional study in female patients with acute cystitis reported good success rates for treatment with <span style="font-variant: small-caps;">d</span>-mannose. Here, we present data from a post hoc analysis of this study to compare the cure rate of <span style="font-variant: small-caps;">d</span>-mannose monotherapy with that of antibiotics. The results show that <span style="font-variant: small-caps;">d</span>-mannose is a promising alternative to antibiotics in the treatment of acute uncomplicated UTIs in women.

Item Description

10.3390/antibiotics11030314
2079-6382