IL-1β and IL-6 Upregulation in Children with H1N1 Influenza Virus Infection

The role of cytokines in relation to clinical manifestations, disease severity, and outcome of children with H1N1 virus infection remains thus far unclear. The aim of this study was to evaluate interleukin IL-1β and IL-6 plasma expressions and their association with clinical findings, disease severi...

Full description

Saved in:
Bibliographic Details
Main Authors: Antonio Chiaretti (Author), Silvia Pulitanò (Author), Giovanni Barone (Author), Pietro Ferrara (Author), Valerio Romano (Author), Domenico Capozzi (Author), Riccardo Riccardi (Author)
Format: Book
Published: Hindawi Limited, 2013-01-01T00:00:00Z.
Subjects:
Online Access:Connect to this object online.
Tags: Add Tag
No Tags, Be the first to tag this record!

MARC

LEADER 00000 am a22000003u 4500
001 doaj_da3e673740a24d14a5dcdf4f018b5be4
042 |a dc 
100 1 0 |a Antonio Chiaretti  |e author 
700 1 0 |a Silvia Pulitanò  |e author 
700 1 0 |a Giovanni Barone  |e author 
700 1 0 |a Pietro Ferrara  |e author 
700 1 0 |a Valerio Romano  |e author 
700 1 0 |a Domenico Capozzi  |e author 
700 1 0 |a Riccardo Riccardi  |e author 
245 0 0 |a IL-1β and IL-6 Upregulation in Children with H1N1 Influenza Virus Infection 
260 |b Hindawi Limited,   |c 2013-01-01T00:00:00Z. 
500 |a 0962-9351 
500 |a 1466-1861 
500 |a 10.1155/2013/495848 
520 |a The role of cytokines in relation to clinical manifestations, disease severity, and outcome of children with H1N1 virus infection remains thus far unclear. The aim of this study was to evaluate interleukin IL-1β and IL-6 plasma expressions and their association with clinical findings, disease severity, and outcome of children with H1N1 infection. We prospectively evaluated 15 children with H1N1 virus infection and 15 controls with lower respiratory tract infections (LRTI). Interleukin plasma levels were measured using immunoenzymatic assays. Significantly higher levels of IL-1β and IL-6 were detected in all patients with H1N1 virus infection compared to controls. It is noteworthy to mention that in H1N1 patients with more severe clinical manifestations of disease IL-1β and IL-6 expressions were significantly upregulated compared to H1N1 patients with mild clinical manifestations. In particular, IL-6 was significantly correlated with specific clinical findings, such as severity of respiratory compromise and fever. No correlation was found between interleukin expression and final outcome. In conclusion, H1N1 virus infection induces an early and significant upregulation of both interleukins IL1β and IL-6 plasma expressions. The upregulation of these cytokines is likely to play a proinflammatory role in H1N1 virus infection and may contribute to airway inflammation and bronchial hyperreactivity in these patients. 
546 |a EN 
690 |a Pathology 
690 |a RB1-214 
655 7 |a article  |2 local 
786 0 |n Mediators of Inflammation, Vol 2013 (2013) 
787 0 |n http://dx.doi.org/10.1155/2013/495848 
787 0 |n https://doaj.org/toc/0962-9351 
787 0 |n https://doaj.org/toc/1466-1861 
856 4 1 |u https://doaj.org/article/da3e673740a24d14a5dcdf4f018b5be4  |z Connect to this object online.