Chemical Composition and Antibacterial Activity of Essential Oils from the Algerian Endemic <i>Origanum glandulosum</i> Desf. against Multidrug-Resistant Uropathogenic <i>E. coli</i> Isolates
Antibiotics are becoming ineffective against resistant bacteria. The use of essential oils (EOs) may constitute an alternative solution to fight against multidrug-resistant bacteria. This study aims to determine the chemical composition of EOs from five populations of the endemic Algerian <i>O...
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| Main Authors: | , , , , , |
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| Format: | Book |
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MDPI AG,
2020-01-01T00:00:00Z.
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| Summary: | Antibiotics are becoming ineffective against resistant bacteria. The use of essential oils (EOs) may constitute an alternative solution to fight against multidrug-resistant bacteria. This study aims to determine the chemical composition of EOs from five populations of the endemic Algerian <i>Origanum glandulosum</i> Desf. and to investigate their potential antibacterial activity against multidrug-resistant uropathogenic <i>E. coli</i> strains. The EOs were obtained by hydrodistillation and their composition was investigated by gas chromatography/mass spectrometry (GC/MS). The antibacterial activity was evaluated by the disc diffusion method against eight <i>E. coli</i> strains (six uropathogenic resistant and two referenced susceptible strains). Minimum inhibitory and bactericidal concentrations (MIC/MBC) were obtained by the broth microdilution method. The main EO components were thymol (15.2−56.4%), carvacrol (2.8−59.6%), <i>γ</i>-terpinene (9.9−21.8%) and <i>p</i>-cymene (8.5−13.9%). The antibacterial tests showed that all the EOs were active against all the strains, including the multidrug-resistant strains. The EO from the Bordj location, which contained the highest amount of carvacrol (59.6%), showed the highest antibacterial activity (inhibition diameters from 12 to 24.5 mm at a dilution of 1/10). To our knowledge, this is the first description of the activity of <i>O. glandulosum</i> EOs against resistant uropathogenic strains. Our study suggests that <i>O. glandulosum</i> EO could be used in some clinical situations to treat or prevent infections (e.g., urinary tract infections) with multidrug-resistant strains. |
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| Item Description: | 2079-6382 10.3390/antibiotics9010029 |