Comparison of the inhibition potentials of icotinib and erlotinib against human UDP-glucuronosyltransferase 1A1

• Main Authors: Xuewei Cheng (Author), Xia Lv (Author), Hengyan Qu (Author), Dandan Li (Author), Mengmeng Hu (Author), Wenzhi Guo (Author), Guangbo Ge (Author), Ruihua Dong (Author)
• Format: Book
• Published: Elsevier, 2017-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

UDP-glucuronosyltransferase 1A1 (UGT1A1) plays a key role in detoxification of many potentially harmful compounds and drugs. UGT1A1 inhibition may bring risks of drug-drug interactions (DDIs), hyperbilirubinemia and drug-induced liver injury. This study aimed to investigate and compare the inhibitor...