Model‐based simulation to support the approval of isatuximab alone or with dexamethasone for the treatment of relapsed/refractory multiple myeloma in Japanese patients

• المؤلفون الرئيسيون: Hoai‐Thu Thai (مؤلف), Kimiko Koiwai (مؤلف), Yoshihisa Shitara (مؤلف), Hirotaka Kazama (مؤلف), Jean‐Baptiste Fau (مؤلف), Dorothée Semiond (مؤلف), Christine Veyrat‐Follet (مؤلف)
• التنسيق: كتاب
• منشور في: Wiley, 2023-12-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

Abstract This study aimed to support dosing regimen selection for isatuximab as a single agent or in combination with dexamethasone for Japanese patients with relapsed/refractory multiple myeloma (RRMM). A joint model characterizing the dynamics of serum M‐protein kinetics and its association with p...