Model‐based simulation to support the approval of isatuximab alone or with dexamethasone for the treatment of relapsed/refractory multiple myeloma in Japanese patients

• Autors principals: Hoai‐Thu Thai (Autor), Kimiko Koiwai (Autor), Yoshihisa Shitara (Autor), Hirotaka Kazama (Autor), Jean‐Baptiste Fau (Autor), Dorothée Semiond (Autor), Christine Veyrat‐Follet (Autor)
• Format: Llibre
• Publicat: Wiley, 2023-12-01T00:00:00Z.
• Matèries: article
• Accés en línia: Connect to this object online.

Abstract This study aimed to support dosing regimen selection for isatuximab as a single agent or in combination with dexamethasone for Japanese patients with relapsed/refractory multiple myeloma (RRMM). A joint model characterizing the dynamics of serum M‐protein kinetics and its association with p...