Comparative effect of different pathogens on the condition of dysbiosis in rat kidneys
<p><strong>Aim</strong>. Compare the effect of different pathogens on the development of kidney dysbiosis.</p><p><strong>Methods</strong>. The pathogens used were hydrazine sulfate, prednisolone, cyclophosphamide, lincomycin, and lipopolysaccharide (LPS). Th...
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| Main Authors: | , , , , , |
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| Format: | Book |
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Kazimierz Wielki University,
2020-12-01T00:00:00Z.
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| Summary: | <p><strong>Aim</strong>. Compare the effect of different pathogens on the development of kidney dysbiosis.</p><p><strong>Methods</strong>. The pathogens used were hydrazine sulfate, prednisolone, cyclophosphamide, lincomycin, and lipopolysaccharide (LPS). The condition of kidney dysbiosis was assessed in rats by a decrease in lysozyme activity and an increase in urease activity.</p><p><strong>Results.</strong> A decrease in the activity of lysozyme in the kidneys under the action of pathogens was established, which, when calculated per 1 mg of a pathogen, is hundreds of times stronger in LPS. All pathogens cause an increase in urease activity in the kidneys, which, when calculated per 1 mg of a pathogen, is hundreds of times stronger in LPS. A similar effect is exerted on the degree of dysbiosis, determined by the ratio of the relative activities of urease and lysozyme.</p><p><strong>Conclusion.</strong> All pathogens (except lincomycin) cause the development of dysbiosis in the kidneys, due to the possible bacteriolysis of tissue gram-negative bacteria with the release of LPS.</p> |
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| Item Description: | 2391-8306 10.12775/JEHS.2020.10.12.003 |