New cyslabdans B and C, potentiators of imipenem activity against methicillin-resistant Staphylococcus aureus produced by Streptomyces sp. K04-0144
From a further purification study, two new congeners designated cyslabdans B (1) and C (2) were isolated along with previously reported cyslabdan (cyslabdan A (3) in this study) from the culture broth of Streptomyces sp. K04-0144. The structure was elucidated by various spectroscopy including NMR, r...
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| Main Authors: | , , , |
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| Format: | Book |
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Elsevier,
2011-12-01T00:00:00Z.
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| Summary: | From a further purification study, two new congeners designated cyslabdans B (1) and C (2) were isolated along with previously reported cyslabdan (cyslabdan A (3) in this study) from the culture broth of Streptomyces sp. K04-0144. The structure was elucidated by various spectroscopy including NMR, revealing that 1 and 2 was 18-hydroxy and 1'-methoxy cyslabdan, respectively. Compounds 1 and 2 were found to potentiate imipenem activity against methicillin-resistant Staphylococcus aureus by 123 fold and 533 fold, respectively. Comparison with the activity of compound 3 indicated that the introduction of a hydrophilic group at the dimethyl moiety of the decalin ring was unfavorable for its activity. |
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| Item Description: | 2211-3835 2211-3843 10.1016/j.apsb.2011.10.008 |