Lipid-Polymer Hybrid Nanoparticles for mRNA Delivery to Dendritic Cells: Impact of Lipid Composition on Performance in Different Media

• Main Authors: Lena Kliesch (Author), Simon Delandre (Author), Aljoscha Gabelmann (Author), Marcus Koch (Author), Kai Schulze (Author), Carlos A. Guzmán (Author), Brigitta Loretz (Author), Claus-Michael Lehr (Author)
• Format: Book
• Published: MDPI AG, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

To combine the excellent transfection properties of lipids with the high stability of polymeric nanoparticles, we designed a hybrid system with a polymeric core surrounded by a shell of different lipids. The aim is to use this technology for skin vaccination purposes where the transfection of dendri...